Check out this very unusual gallery. It's a real window on the New York artist and his/her work. Shows can be interesting forays into small gauge film and experimental video and often exhibit very unusual, collectible pieces.
The neighborhood is also extremely colorful and brings back memories of the old alphabet city scene- and, even further back in time- the maybe safe-maybe sorry Soho loftscene. Best to see it before gentrification arrives---and it's gone.